Photodynamic Therapy for Cancer Treatment
Photodynamic therapy (PDT) is a fairly new modality for treatment and management of cancers with the potentials of minimal side-effect and probability of no secondary malignancy. PDT treatment currently consists of IV injection of a photosensitizer drug in a patient followed by illuminating the patient with visible/infrared light to the tumor bed to induce the tumor cell death or vasculature shutdown. While significant research resources have been pursued worldwide since 1980s, the complex process of human tissues as a turbid media interacting with photosensitizer and light has impeded the clear understanding of the PDT dosimetry and wide application in clinics. The research efforts on PDT in our lab are focused on quantitative modeling of PDT process in cell models and development of Monte Carlo based PDT planning system for clinical applications.
J.Q. Lu, C.H. Sibata, R. S. Brock, R. R. Allison, G. H. Downie, R. E. Cuenca, X.H. Hu, “Optimization of PDT Treatment with Multiple Laser Beams Using a Parallel Monte Carlo Code”, to be presented in AAPM Annual Meeting 2003, San Diego, California (abstract: Medical Physics, 30, 1513 (2003))
X.H. Hu, J.Q. Lu, R. R. Allison, G. H. Downie, R. E. Cuenca, C.H. Sibata -Monte Carlo Based Model of Photodynamic Therapy Process”, to be presented in AAPM Annual Meeting 2003, San Diego, California (abstract: Medical Physics, 30, 1513 (2003))
R.R. Allison, G.H. Downie, R.E. Cuenca, X.H. Hu, C.J.H. Childs, C.H. Sibata, “Photosensitizers in clinical PDT”, Photodiagnosis and Photodynamic Therapy, 1, 27-42 (2004)
R.R. Allison, C. Sibata, T.S. Mang, V.S. Bagnato, G.H. Downie, X.H. Hu, R. Cuenca, “Photodynamic therapy for chest wall recurrence from breast cancer”, Photodiagnosis and Photodynamic Therapy, 1, 157-171 (2004)
X.H. Hu, Y. Feng, J.Q. Lu, R.R. Allison, R.E. Cuenca, G.H. Downie, C.H. Sibata, “Modeling of a type II Photofrin-Mediated photodynamic therapy process in a heterogeneous tissue phantom”, Photochemistry and Photobiology , 81, 1460-1468 (2005)
I. Gkigkitzis, Y. Feng, C. Yang, J. Q. Lu, X. H. Hu, “Modeling of oxygen transport and cell killing in type II photodynamic therapy”, Photochemistry and Photobiology, 88, 969–977 (2012)