Photodynamic Therapy
for Cancer Treatment
|
Description Photodynamic therapy (PDT) is a
fairly new modality for treatment and management of cancers with the
potentials of minimal side-effect and probability of no secondary malignancy.
PDT treatment currently consists of IV injection of a photosensitizer drug in
a patient followed by illuminating the patient with visible/infrared light to
the tumor bed to induce the tumor cell death or vasculature shutdown. While
significant research resources have been pursued worldwide since 1980s, the
complex process of human tissues as a turbid media interacting with
photosensitizer and light has impeded the clear understanding of the PDT
dosimetry and wide application in clinics. The research efforts on PDT in our
lab are focused on quantitative modeling of PDT process in cell models and
development of Monte Carlo based PDT planning system for clinical
applications. Publications · J.Q. Lu, C.H. Sibata, R. S. Brock, R. R. Allison, G. H. Downie, R. E. Cuenca, X.H. Hu, “Optimization of PDT Treatment with Multiple Laser Beams Using a Parallel Monte Carlo Code”, to be presented in AAPM Annual Meeting 2003, San Diego, California (abstract: Medical Physics, 30, 1513 (2003)) ·
X.H. Hu, J.Q.
Lu, R. R. Allison, G. H. Downie, R. E. Cuenca, C.H. Sibata -Monte Carlo Based
Model of Photodynamic Therapy Process”, to be presented in AAPM Annual
Meeting 2003, San Diego, California (abstract: Medical Physics, 30,
1513 (2003)) · R.R. Allison, G.H. Downie, R.E. Cuenca, X.H. Hu, C.J.H. Childs, C.H. Sibata, “Photosensitizers in clinical PDT”, Photodiagnosis and Photodynamic Therapy, 1, 27-42 (2004) |